DMCCB Basel Symposium 2018: Novel Chemical Space and Tools for Chemical Bioligy, Medicinal and Agrochemistry, Basel, 14th May 2018

摘要

The 2018 DMCCB Basel symposium organized by the Swiss Chemical Society (SCS) focused on 'Novel Chemical Space and Tools for Chemical Biology, Medicinal and Agrochemistry'. For the second time, the topic of the conference was selected by vote of the members of the medicinal chemistry and chemical biology division (DMCCB). The conference opened with an enlightening lecture by Alleyn Plowright, current Head of Integrated Drug Discovery at Sanofi Germany, titled 'Joining forces: application of Chemical Biology and Medicinal Chemistry to discover novel biological tools and utilise new therapeutic modalities'. Sharing his experience in several major research projects, Plowright highlighted the importance of so-called 'new modalities' in drug discovery. These 'new modalities' include altered peptides which are used to address non-classical targets such as protein-protein interactions (PPIs). By introducing the example of a novel Melanocortin Receptor Agonist, he reminded the audience of the importance of factors such as chemical stability and cell permeability and the need to consider these aspects as early as possible in a drug discovery project.