Expanding Mg–Zn Hybrid Chemistry: Inorganic Salt Effects in Addition Reactions of Organozinc Reagents to Trifluoroacetophenone and the Implications for a Synergistic Lithium–Magnesium–Zinc Activation

摘要

Numerous organic transformations rely on organozinc compounds made through salt-metathesis (exchange) reactions from organolithium or Grignard reagents with a suitable zinc precursor. By combining X-ray crystallography, NMR spectroscopy and DFT calculations, this study sheds new light on the constitution of the organometallic species involved in this important synthetic tool. Investigations into the metathesis reactions of equimolar amounts of Grignard reagents (RMgX) and ZnCl₂ in THF led to the isolation of novel magnesium–zinc hybrids, [{(thf)₂Mg(μ-Cl)₃ZnR}₂] (R=Et, tBu, nBu or o-OMe-C₆H₄), which exhibit an unprecedented structural motif in mixed magnesium–zinc chemistry. Furthermore, theoretical modelling of the reaction of EtMgCl with ZnCl₂ reveals that formation of the mixed-metal compound is thermodynamically preferred to that of the expected homometallic products, RZnCl and MgCl₂. This study also assesses the alkylating ability of hybrid 3 towards the sensitive ketone trifluoroacetophenone, revealing a dramatic increase in the chemoselectivity of the reaction when LiCl is introduced as an additive. This observation, combined with recent related breakthroughs in synthesis, points towards the existence of a trilateral Li/Mg/Zn synergistic effect.