Cyclic Carbopalladation. A Versatile Synthetic Methodology for the Construction of Cyclic Organic Compounds

摘要

Carbopalladation of alkenes, alkynes, allenes, conjugated dienes, and other related π-compounds provides a general, versatile, stereoselective, and chemoselective methodology for carbon—carbon bond formation. In particular, the Heck reaction involving alkenes has been extensively developed and widely used in organic synthesis. Its cyclic version provides attractive routes to common and large rings, and it has recently been applied to the synthesis of natural products and other complex organic compounds. Undoubtedly, many additional applications must be forthcoming. In this connection, further development of both diastereoselective and enantioselective procedures appears to be highly desirable.