A protective coating helps fine powders flow, without agglomeration

摘要

A team from Monash Institute of Pharmaceutical Science at Monash University, has developed an approach -- a hybrid mixing and milling process -- for producing fine (1-20 µm) pharmaceutical powders with good flow and de-agglomeration properties. The team used a very high shear system -- a Nobilta "Mechanofusion" processor developed by Hosokawa Micron Corp -- that has a specially designed fast blade, providing a fast moving compressive surface. The process the team has developed involves coating the particles with a nano-layer of an additive, which is polished into the particles' surface.