Encoded combinatorial libraries for the construction of cyclic peptoid microarrays

摘要

A "one bead two compound" approach to the synthesis of encoded cyclic peptoid libraries is reported.rnDrug-like small molecules (<500 Daltons) generally do not bind well to the relatively shallow surfaces of proteins involved in protein-protein interactions. Thus, in order to develop effective therapeutic agents against these increasingly important targets, it is necessary to develop libraries of compounds able to cover a greater surface area and engage in multiple contacts with the target protein, as well as efficient methods to screen these libraries. With regard to their protein-binding properties, peptides are an attractive class of molecules, but linear peptides have many undesirable features.