Asymmetric Synthesis Of Either Diastereomer Of Trifluoromethylated Allylic Amines By The Selective Reduction Of Trifluoromethyl α,β-unsaturated N-tert-butanesulfinyl Ketoimines

摘要

Regio- and diastereoselective reduction of chiral trifluoromethyl α, β-unsaturated N-tert-butanesulfinyl ketoimines 1 was achieved by choosing appropriate reducing agent and either diastereomer of the corresponding trifluoromethylated allylic amines was obtained with good yield and excellent diastereoselectivityrn(up to >99 : 1 dr).