Trimethylaluminium mediated amide bond formation in a continuous flow mlcroreactor as key to the synthesis of rimonabant and efaproxiral

摘要

A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.