Electrical control of cell density gradients on a conducting polymer surface

摘要

We describe a conducting polymer device that can induce electrically controlled density gradients of normal and cancerous cell lines, and hence can be used as a tool for the study of cell-cell interactions.rnGradients in cell density control the functions of normal and pathological tissues by regulating the quality and quantity of cell-cell interactions. For example, spatial variations in cell density lead to the generation of growth factor gradients, which, in turn, influence cell migration, proliferation, and differentiation.