Synthesis of substituted pyridines and pyridazines via ring closing metathesis

摘要

RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system.rnIn recent years we have been engaged in a research programme that has been devoted to exploring the synthesis of aromatic heterocycles using ring closing metathesis (RCM) as the key C-C bond forming step. Considering the enormous impact that RCM has had on organic synthesis, it is surprising that there is relatively little known in the literature regarding the production of aromatic systems using this chemistry. This is especially striking given the high impact that aromatic compounds have made in many different areas of organic chemistry, especially within the pharmaceutical industry.