Total synthesis of (+ )-A83586C, (+ )-kettapeptin and (+ )-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

摘要

Herein we describe our asymmetric total syntheses of ( + )-A83586C, ( + )-kettapeptin and ( + )-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.