Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

Jessie Jing Yan; Andy Lok-Fung Chow; Chung-Hang Leung; Raymond Wai-Yin Sun; Dik-Lung Ma; Chi-Ming Che

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Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

机译：具有N-杂环卡宾配体的环金属化金（III）配合物作为拓扑异构酶I毒物

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A panel of stable [Au(R-C~^N~^C)(N-heterocyclic carbene)]~+ complexes displays prominent in vitro anticancer properties; [Au(C~^N~^C)(IMe)]CF_3SO_3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

机译：一组稳定的[Au（R-C〜^ N〜^ C）（N-杂环卡宾）] +复合物显示出显着的体外抗癌特性； [Au（C〜^ N〜^ C）（IMe）] CF_3SO_3（1，IMe = 1,3-二甲基咪唑-2-亚基）在体外显着毒性拓扑异构酶I，并抑制裸鼠模型中的肿瘤生长。

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来源
《Chemical Communications》 |2010年第22期|P.3893-3895|共3页
作者
Jessie Jing Yan; Andy Lok-Fung Chow; Chung-Hang Leung; Raymond Wai-Yin Sun; Dik-Lung Ma; Chi-Ming Che;
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作者单位

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

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入库时间 2022-08-17 13:23:49

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Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

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