Chirality from achiral components: N, N/'-bis(4-dimethylaminobenzyl)dodecane-1, 12-diammonium in cucurbit[8]uril

摘要

The long alkyl chain of N,N'-bis(4-dimethylaminobenzyl)-dodecane-1,12-diamine (C_(12)DA) adopts different chiral helical conformations, one left-handed and the other right-handed, when bound within the cavities of two distorted cucurbit[8]uril (Q[8]) units, as unequivocally established by X-ray crystallography.rnAlkanes usually adopt fully extended conformations in solution, the gas phase and the solid state, that minimizes steric interactions and maximizes surface area. However, alkanes can adopt contorted conformations, such as helices or U-shapes, when bound within some natural and synthetic hydrophobic receptors.