Catalytic S_NAr reaction of non-activated fluoroarenes with amines via Ru η~6-arene complexes

摘要

Ru-catalyzed S_NAr reaction of non-activated fluoroarenes with secondary amines proceeded through η~6-arene complexes to give animated products in up to 79% yield.The nucleophilic aromatic substitution (S_NAr) reaction of haloarenes is a widely used transformation in organic syntheses; multi-substituted arenes, including several pharmaceutical products and natural products, have been synthesized using this method. However, the S_NAr reaction generally requires "electron-poor" aromatic compounds with strong electron-withdrawing group(s), such as nitro and cyano groups, because the aromatic ring is intrinsically electron-rich, and haloarenes without electron-withdrawing group(s), namely non-activated haloarenes, are not suitable as electro-philes in the S_NAr reaction.