Ruthenium(II) polypyridyl complexes as carriers for DNA delivery

Satish S. Bhat; Avinash S. Kumbhar; Anupa A. Kumbhar; Ayesha Khan; Peter Loennecke; Evamarie Hey-Hawkins

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Ruthenium(II) polypyridyl complexes as carriers for DNA delivery

机译：钌（II）聚吡啶配合物作为DNA传递的载体

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Two novel water soluble ruthenium(II) complexes [Ru(bpy)_2(bqbg)]~(2+) and [Ru(phen)_2(bqbg)]~(2+) have been structurally characterized and their DNA condensation activity, cytotoxicity, and cellular uptake studies of DNA condensates as potential non-viral DNA carriers were evaluated.

机译：对两种新型水溶性钌（II）配合物[Ru（bpy）_2（bqbg）]〜（2+）和[Ru（phen）_2（bqbg）]〜（2+）进行了结构表征，并确定了它们的DNA缩合活性，评估了作为潜在的非病毒DNA载体的DNA冷凝物的细胞毒性和细胞摄取研究。

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《Chemical Communications》 |2011年第39期|p.11068-11070|共3页
作者
Satish S. Bhat; Avinash S. Kumbhar; Anupa A. Kumbhar; Ayesha Khan; Peter Loennecke; Evamarie Hey-Hawkins;
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作者单位

Department of Chemistry, University of Pune, Pune- 411007, India;

Department of Chemistry, University of Pune, Pune- 411007, India;

Department of Chemistry, University of Pune, Pune- 411007, India;

Institute of Bioinformatics and Biotechnology, University of Pune, India;

Faculty of Chemistry and Mineralogy, Department of Inorganic Chemistry, Universitaet Leipzig, Johannisallee 29, Leipzig, Germany;

Faculty of Chemistry and Mineralogy, Department of Inorganic Chemistry, Universitaet Leipzig, Johannisallee 29, Leipzig, Germany;

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1. Effects of intercalative ligands on the DNA binding, DNA topoisomerase II and DNA transcription inhibition of polypyridyl ruthenium(II) complexes [J] . Chen X., Gao F., Yang W.-Y., Inorganica Chimica Acta . 2011,第1期

机译：插层配体对聚吡啶钌（II）复合物的DNA结合，DNA拓扑异构酶II和DNA转录抑制的影响
2. Reactivity studies Of eta(6)-arene ruthenium (II) dimers with polypyridyl ligands: isolation of mono, binuclear p-cymene ruthenium (II) complexes and bisterpyridine ruthenium (II) complexes [J] . Lalrempuia R., Kollipara MR. Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2003,第23期

机译：带有吡啶基配位体的eta（6）-芳烃钌（II）二聚体的反应性研究：单，双核对异丙基钌（II）配合物和双吡啶吡啶（II）配合物的分离
3. Ruthenium (II) polypyridyl complexes based on bipyridine and two novel diimine ligands with carrier-transporting unit: Synthesis, photoluminescence and redox properties [J] . WuJ., LiH.-Y., KangL.-C., Journal of Organometallic Chemistry . 2010,第17期

机译：基于联吡啶和两个具有载流子传输单元的新型二亚胺配体的钌（II）聚吡啶基配合物：合成，光致发光和氧化还原性质
4. MALDI TOF MASS SPECTROMETRY FOR THE CHARACTERIZATION OF ANTITUMOUR RUTHENIUM(II) POLYPYRIDYL COMPLEXES [C] . Romana Masnikosa, Filip Veljkovic, Boris Rajcic, International Mass Spectrometry Conference . 2018

机译：MALDI TOF质谱法用于表征抗胃钌（II）聚吡啶络合物
5. Structure-activity relationships of ruthenium(II) polypyridyl complexes with redox-active intercalating ligands: Correlation between redox activity, DNA cleavage capability and cytotoxicity. [D] . Narh, Eugenia Soyo. 2015

机译：钌（II）聚吡啶基配合物与氧化还原活性的嵌入配体的结构活性关系：氧化还原活性，DNA裂解能力和细胞毒性之间的相关性。
6. Chiral Ruthenium(II) Polypyridyl Complexes: Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Cellular Uptake [O] . Qianqian Yu, Yanan Liu, Chuan Wang, 2009

机译：手性钌（II）聚吡啶基配合物：稳定的G四联体DNA，抑制端粒酶活性和细胞摄取。
7. A New Strategy for Improvement of Photophysical Properties in Ruthenium(II) Polypyridyl Complexes. Synthesis, Photophysical and Electrochemical Characterisation of Six Mononuclear Ruthenium(II) Bisterpyridine Type Complexes [O] . Abrahamsson, Maria, Wolpher, Henriette, Johansson, Olof, 2005

机译：提高钌（II）多吡啶配合物光物理性质的新策略。六种单核钌（II）Bisterpyridine型配合物的合成，光物理和电化学表征
8. Polypyridyl-Hydrido Complexes of Osmium(II) And Ruthenium(II) [R] . Caspar, J. V., Sullivan, B. P., Meyer, T. J. 1982

机译：锇（II）和钌（II）的多吡啶基 - 氢化物配合物

Ruthenium(II) polypyridyl complexes as carriers for DNA delivery

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