Programmed placement of gold nanoparticles onto a slit-type DNA origami scaffold

摘要

The programmed arrangement of functional molecules and nanomaterials is one of the major goals in bottom-up nano-technology.1'2 DNA is the most promising of molecules for the creation of various self-assembled components and scaffolds, and for selective placement of functional molecules and nanomaterials.1'2 The DNA origami method, developed for the preparation of fully addressable two-dimensional (2D) structures,3-6 has been utilized for the selective positioning of functional molecules and nanoparticles,7-11 programmed arrangements,12 molecular machines,13 and for the design of various 3D architectures.14 Patterning of multiple AuNPs into the designed nanostructures can be applied for the construction of the plasmonic waveguide and circuits.15 For the further development of the programmed placement of multiple AuNPs into various 2D patterns, a novel scaffold should be explored. This was performed by designing a DNA origami and selecting the DNA sequences for the attachment of AuNPs at target positions.