HYDRAmevs: design, synthesis and characterization of different generation novel Hydra-like dendrons based on multifunctionalized adamantane

摘要

In this communication we present a new synthetic strategy to different generation Hydra-like dendrons based on tetra-functionalized adamantane as a building block. The novel dendrons, which we termed HYDRAmers, possess at the periphery and at the central core orthogonal protections that can be exploited for conjugation of targeting ligands, drugs and/or imaging probes. In the biomedical field, dendrimers and the so-called "dendrons" (wedge-shaped dendrimer sections)1 are very promising as the diversity of functionalization brought by the arborescent structure simultaneously solves the problems of biocompatibility, toxicity, in vivo stability and specificity.