A facile, modular and high yield method to assemble three-dimensional DNA structures

摘要

We describe a rapid and quantitative method to generate DNA cages of deliberately designed geometry from readily available starting strands. Balancing the incorporation of sequence uniqueness and symmetry in a face-centered approach to 3D construction can result in triangular (TP), rectangular (RP), and pentagonal prisms (PP) without compromising the potential for nanostructure addressability. The construction of three-dimensional (3D) assemblies is a long-standing goal in supramolecular chemistry.