Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray

摘要

The binding of seven multivalent glycoconjugates displaying linear or antenna-like structures and different electronic environments were evaluated towards PA-IL on a DNA-based carbohydrate microarray. The affinity can be modulated by the charge and the topology of the galactosylated derivatives. Carbohydrate-lectin interactions play an important role in several biological processes, such as cell-cell communication, inflammation, innate system and viral or bacterial infections.