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Reactive oxygen species in photochemistry of the red fluorescent protein 'Killer Red'

机译:红色荧光蛋白“杀手红”的光化学中的活性氧

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摘要

The fluorescent protein aptly named "Killer Red" (KRed) is capable of killing transfected cells and inactivating fused proteins upon exposure to visible light in the presence of oxygen. We have investigated the source of the bioactive species through a variety of photophysical and photochemical techniques. Our results indicate a Type I (electron transfer mediated) photosensitizing mechanism.
机译:适当地称为“杀手红”(KRed)的荧光蛋白能够杀死转染的细胞,并在有氧存在下暴露于可见光下使融合的蛋白失活。我们已经通过各种光物理和光化学技术研究了生物活性物种的来源。我们的结果表明了I型(电子转移介导)光敏机理。

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  • 来源
    《Chemical Communications》 |2011年第17期|p.4887-4889|共3页
  • 作者单位

    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA,Parker H. Petit Institute of Bioengineering and Biosciences,Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA;

    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA;

    Chemistry Department, Imperial College London, Exhibition Road,South Kensington, London, UK SW7 2AZ;

    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA,Parker H. Petit Institute of Bioengineering and Biosciences,Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA;

    Parker H. Petit Institute of Bioengineering and Biosciences,Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA,School of Chemical and Biomolecular Engineering,Georgia Institute of Technology, Atlanta, Georgia 30332-0100, USA;

    Parker H. Petit Institute of Bioengineering and Biosciences,Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA,School of Chemical and Biomolecular Engineering,Georgia Institute of Technology, Atlanta, Georgia 30332-0100, USA;

    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA;

    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA,Parker H. Petit Institute of Bioengineering and Biosciences,Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA,School of Chemical and Biomolecular Engineering,Georgia Institute of Technology, Atlanta, Georgia 30332-0100, USA;

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  • 入库时间 2022-08-17 13:22:18

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