A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy

Haihua Xiao; Lesan Yan; Yu Zhang; Ruogu Qi; Wenliang Li; Rui Wang; Shi Liu; Yubin Huang; Yuxin Li; Xiabin Jing

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A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy

机译：双靶杂合铂（iv）前药以增强功效

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摘要

A multifunctional hybrid platinum(iv) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crossiinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intra-cellular delivery.

机译：合成了一种多功能杂合铂（iv）前药，该药由线粒体靶向药物DCA和DNA交叉药物顺铂组成，并束缚在载体聚合物上，以进一步自组装成胶束用于细胞内递送。

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来源
《Chemical Communications》 |2012年第87期|p.10730-10732|共3页
作者
Haihua Xiao; Lesan Yan; Yu Zhang; Ruogu Qi; Wenliang Li; Rui Wang; Shi Liu; Yubin Huang; Yuxin Li; Xiabin Jing;
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作者单位

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China ,Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China ,Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, People's Republic of China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China ,Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China ,Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China ,Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China ,Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;

National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, People's Republic of China;

Stale Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;

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入库时间 2022-08-17 13:21:04

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1. The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy [J] . XiaoH., SongH., ZhangY., Biomaterials . 2012,第33期

机译：聚合铂（IV）前药用于递送具有降低的全身毒性和增强的抗肿瘤功效的多核铂（II）药物
2. The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy [J] . XiaoH., SongH., ZhangY., Biomaterials . 2012,第33期

机译：聚合铂（IV）前药用于递送具有降低的全身毒性和增强的抗肿瘤功效的多核铂（II）药物
3. Improving the anticancer activity of platinum(iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand [J] . Liu Fengfan, Dong Xiaomei, Shi Qiwen, RSC Advances . 2019,第39期

机译：使用双靶向策略提高铂（IV）前药的抗癌活性用二氯乙酸二氯乙酸轴配体
4. Thermal and Spectroscopic Characterization of Platinum(IV) Prodrug Candidates [C] . B.A. Howell, P. Chhetri, A. Dumitrascu Annual Conference of the North American Thermal Analysis Society . 2013

机译：铂（IV）前药候选物的热和光谱表征
5. Mechanism of Action and Gold Nanoparticle Delivery of Platinum(IV) Prodrugs of Cisplatin [D] . Shi, Yi 2012

机译：顺铂铂（IV）前药的作用机理和金纳米颗粒传递
6. αVβ3 Integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug [O] . Nora Graf, Diane R. Bielenberg, Nagesh Kolishetti, -1

机译：αvβ3整合蛋白靶向PLGA-PEG纳米颗粒用于增强Pt（IV）前药的抗肿瘤效果
7. Improving the anticancer activity of platinum(iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand [O] . Fengfan Liu, Xiaomei Dong, Qiwen Shi, 2019

机译：使用双靶向策略提高铂（IV）前药的抗癌活性用二氯乙酸二氯乙酸轴配体

A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy

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