A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gpl20 on a TAC synthetic scaffold

摘要

We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in FHV-gpl20, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.