Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivativest

摘要

Several α-alkylated β-amino esters have been obtained via OKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic p-keto esters high to excellent inductions were obtained.