Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(Ⅰ) site that is resistant to O_2 oxidation

摘要

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(Ⅱ) coordination yields a square planar (N/0)_4 coordination environment, while reduction yields an O_2 inert linear bis-His Cu(Ⅰ) centre.