Translating the concept of peptide labeling with 5-deoxy-5-[~(18)F]fluororibose into preclinical practice:~(18)F-labeling of Siglec-9 peptide for PET imaging of inflammation

摘要

Peptide glycosylation with 5-deoxy-5-[~(18)F]fluororibose was translated into preclinical settings. The novel ~(18)F-labeled Siglec-9 peptide was produced using an automated synthesis procedure. The ~(18)F-labeled Siglec-9 peptide showed favorable binding in the animal model of inflammation in vivo.