Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

摘要

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional ~(12)C/~1H and heavy stable isotope ~(13)C/~2H-labeled chelator-amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.