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首页> 外文期刊>Chemical Communications >~(18)F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease
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~(18)F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

机译：〜（18）F-巴比妥酸酯是PET示踪剂，对阿尔茨海默氏病具有诊断潜力

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摘要

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [~(18)F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [~(18)F]1a identified p-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(Ⅱ) indicator.
机译：合成了三种氟巴比妥酸盐，显示出体内镇静效果。其中之一[〜（18）F] 1a以放射性氟化形式合成。与野生型和tau系相比，用[〜（18）F] 1a进行PET / CT成像可鉴定出p-淀粉样蛋白过表达的转基因小鼠（βA小鼠）。荧光巴比妥酸盐9能够标记βA小鼠脑部的βA斑块，并与荧光Zn（Ⅱ）指示剂共定位。

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  • 来源
    《Chemical Communications》 |2013年第8期|792-794|共3页
  • 作者

    Elisa Calamai; Sergio DallAngelo; David Koss; Juozas Domarkas; Timothy J. McCarthy; Marco Mingarelli; Gernot Riedel; Lutz F. Schweiger; Andy Welch; Bettina Platt; Matteo Zanda;

  • 作者单位

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Precision Medicine, Pfizer WRD, Groton, CT, USA;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences and J. Mallard Scottish PET Centre, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD,Scotland, UK;

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  • 入库时间 2022-08-17 13:17:51

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