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首页> 外文期刊>Chemical Communications >In cell scalaradial interactome profiling using a bio-orthogonal clickable probe
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In cell scalaradial interactome profiling using a bio-orthogonal clickable probe

机译：使用生物正交可点击探针进行细胞sc骨相互作用基因组分析

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摘要

A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several biophysical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets.
机译：开发了一种生物正交点击化学程序，以实现allow骨抗炎海洋天然产物sc内的细胞内相互作用组分析。通过经典的体外化学蛋白质组学和几种生物物理方法的应用验证了结果。过氧化物酶，14-3-3亚型和蛋白酶体被认为是主要的ala骨靶标。

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  • 来源
    《Chemical Communications》 |2014年第45期|6043-6045|共3页
  • 作者

    C. Cassiano; L. Margarucci; R. Esposito; R. Riccio; A. Tosco; A. Casapullo; M. C. Monti;

  • 作者单位

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ132, 84084, Fisciano, Salerno, Italy;

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ 132, 84084, Fisciano, Salerno, Italy;

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ132, 84084, Fisciano, Salerno, Italy;

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ132, 84084, Fisciano, Salerno, Italy;

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ132, 84084, Fisciano, Salerno, Italy;

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ132, 84084, Fisciano, Salerno, Italy;

    Department of Pharmacy, University of Salerno, Via Giovanni Paolo Ⅱ132, 84084, Fisciano, Salerno, Italy;

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  • 入库时间 2022-08-17 13:15:51

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