Elucidation of the mechanism of chiral selectivity in diastereomeric salt formation using organic solvent nanofiltration

摘要

Organic solvent nanofiltration (OSN) was used to investigate the mechanism of chiral selectivity in diastereomeric salt formation of α-phenylethylamine with D-tartaric acid and di-p-toluoyl-D-tartaric acid as resolving agents; results indicate that for these systems chiral selectivity occurs only upon crystallisation and chiral interactions in solution were negligible.