Chemical optimization of artificial metalloenzymes based on the biotin-avidin technology:(S)-selective and solvent-tolerant hydrogenation catalysts via the introduction of chiral amino acid spacers

摘要

Incorporation of biotinylated-[rhodium(diphosphine)]~+ complexes,with enantiopure amino acid spacers,in streptavidin affords solvent-tolerant and selective artificial metalloenzymes:up to 91% ee (5) in the hydrogenation of N-protected dehydroamino acids.