Nickel-catalyzed coupling of isocyanates with 1,3-iodoesters and halobenzenes: a novel method for the synthesis of imide and amide derivatives

摘要

Substituted imide and amide derivatives were conveniently prepared from the reaction of isocyanates with omicron-iodobenzoates and haloarenes catalyzed by the NiBr_2(dppe)/dppe/Zn system in moderate to good yields with excellent tolerance of functional groups.Isocyanate derivatives are very reactive species,but the application of isocyanates is mostly limited to the synthesis of urethane or urea derivatives.Only recently,transition metal-mediated cycloaddi-tion of isocyanates with alkynes to form pyridones has attracted considerable attention.On the other hand,imides are important industrial,biological and medicinal chemicals.