Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media

摘要

Among novel bis-nucleobase-phenanthridinium conjugates bis-uracil analogue 2 stabilized significantly more effective poly-dA - poly-dT and poly-AH(+)-poly-AH(+) than adenine analogue 3 and reference compound 1. For the alternating poly-dAdT-poly- dAdT however, the binding preference is lost, pointing to the importance of specific interactions of uracils of 2 with homopolynucleotides containing consecutive adenines.