Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor

Bhagavathy Shanmugasundaram; Aleksandra W.Debowski; Rebecca J.Dennis

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Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor

机译：葡萄糖配置的那格他汀和PUGNAc-咪唑杂化抑制剂对O-GlcNAcase的抑制作用

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Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.The substitution of serine and threonine residues of nucleocyto-plasmic proteins with 2-acetamido-2-deoxy-beta-D-glucopyranose (OGlcNAc)residues is an essential post-translational modification found within all multicellular eukaryotes.

机译：PUGNAc-咪唑杂合体的合成及其通过酶动力学和X射线结构分析表征为人O-GlcNAcase抑制剂。用2-acetamido-2-deoxy-beta取代核浆蛋白的丝氨酸和苏氨酸残基-D-吡喃葡萄糖（OGlcNAc）残基是在所有多细胞真核生物中发现的重要的翻译后修饰。

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来源
《Chemical Communications》 |2006年第42期|p.4372-4374|共3页
作者
Bhagavathy Shanmugasundaram; Aleksandra W.Debowski; Rebecca J.Dennis;
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Laboratorium fur Organische Chemie,HC1 H 317,ETH Zurich,CH-8093 Zurich,Switzerland.;

Department of Chemistry,Simon Eraser University,8888 University Drive,Burnaby,Canada.;

Department of Chemistry,The University of York,Heslington,York,UK YO105YW.;

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正文语种 eng
中图分类化学;
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入库时间 2022-08-17 13:30:15

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1. Erratum: Inhibition of O-glcnacase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes (Chemistry and Biology (2010) 17 (937-948)) [J] . MacAuley M.S., He Y., Gloster T.M., Chemistry & biology . 2010,第10期

机译：勘误：使用有效且可渗透细胞的抑制剂抑制O-glcnacase不会在3T3-L1脂肪细胞中诱导胰岛素抵抗（Chemistry and Biology（2010）17（937-948））
2. Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes [J] . MacAuley M.S., He Y., Gloster T.M., Chemistry & biology . 2010,第9期

机译：使用有效且可渗透细胞的抑制剂抑制O-GlcNAcase不会在3T3-L1脂肪细胞中诱导胰岛素抵抗
3. Differential inhibition of GH family 11 endo-xylanase by rice xylanase inhibitor and verification by a modified yeast two-hybrid system [J] . Liu Mingqi, Wu Xiaoqian, Huo Wenkang, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2019,第期

机译：水稻木聚糖酶抑制剂对GH系列11内甲酰酶的差异抑制及改性酵母双杂交系统的验证
4. Relationships between Inhibition Constants, Types of Inhibition and IC50: Calculation and Comparison on IC50 of Two Model Tyrosinase Inhibitors [C] . Mao Hairong, Xie Jiangang, Zhang Qimeng, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：抑制常数，抑制类型与IC50之间的关系：两种模型酪氨酸酶抑制剂的IC50计算和比较
5. Corrosion Inhibition of Aluminum Alloy 2024-T3 Based on Smart Coatings, Hybrid Corrosion Inhibitions, and Organic Conversion Coatings. [D] . Guo, Xiaolei. 2016

机译：基于智能涂层，混合腐蚀抑制剂和有机转化涂层的铝合金2024-T3的腐蚀抑制。
6. Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes [O] . Matthew S. Macauley, Yuan He, Tracey M. Gloster, -1

机译：使用有效的和可渗透细胞的抑制剂抑制O-GlcNAcase不会诱导3T3-L1脂肪细胞中的胰岛素抵抗。
7. Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes [O] . Macauley, M.S., He, Y., Gloster, T.M., 2010

机译：使用有效的和可渗透细胞的抑制剂抑制O-GlcNAcase不会诱导3T3-L1脂肪细胞中的胰岛素抵抗。

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor

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