Synthesis of Highly Substituted Pyridines Over Zeolite Molecular Sieves Under High Pressure

摘要

Simple and selective single step synthesis of highly substituted pyridines (trisubstituted pyridines) from aliphatic aldehydes and aqueous ammonia using zeolite as a catalyst under high pressure (autogenous pressure) conditions with high conversion and moderate selectivity is presented. The catalyst can be reused many times without significant loss of activity.