Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts

摘要

Objective: Because ouabain activates several pathways that are critical to cardioprotective mechanisms such as ischemic preconditioning, we tested if this digitalis compound could protect the heart against ischemia–reperfusion injury through activation of the Na+,K+-ATPase/c-Src receptor complex.