K_ATP activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function

摘要

Aims We investigated the effects of iptakalim, a new ATP-sensitive potassium channel (K_ATP) opener providing endothelial protection, on the progression of cardiac hypertrophy to failure in a rat model of pressure overloading caused by abdominal aortic banding (AAB). Endothelial dysfunction is central to cardiac hypertrophy and failure induced by pressure overload. It would be useful to clarify whether iptakalim could prevent this.