A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)

Petr Sova; Adolf Mistr; Ales Kroutil; Martin Semerád; Hana Chlubnová; Veronika Hrusková; Jirina Chládková; Jaroslav Chládek

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A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)

机译：单次口服两种铂（IV）配合物LA-12（OC-6-43）-双（乙酰基）（1-金刚烷基胺）氨基二氯铂的大鼠体内铂的药代动力学，尿排泄和组织分布的比较研究（IV）和沙铂（OC-6-43）-双（乙酰基）氨基二氯（环己胺）铂（IV）

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Purpose This study compared the pharmacokinetics, tissue distribution, and urinary excretion of platinum in rats after single oral doses of LA-12 and satraplatin.

机译：目的本研究比较了单次口服LA-12和沙铂后大鼠体内铂的药代动力学，组织分布和尿排泄。

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《Cancer Chemotherapy and Pharmacology》 |2011年第6期|p.1247-1256|共10页
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Petr Sova; Adolf Mistr; Ales Kroutil; Martin Semerád; Hana Chlubnová; Veronika Hrusková; Jirina Chládková; Jaroslav Chládek;
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入库时间 2022-08-18 01:47:27

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1. A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV). [J] . Sova P, Mistr A, Kroutil A, Cancer chemotherapy and pharmacology. . 2011,第6期

机译：单次口服两种铂（IV）配合物LA-12（OC-6-43）-双（乙酰基）（1-金刚烷基胺）氨基二氯铂的大鼠体内铂的药代动力学，尿排泄和组织分布的比较研究（IV）和沙铂（OC-6-43）-双（乙酰基）氨基二氯（环己胺）铂（IV）。
2. Pharmacokinetics and tissue distribution of platinum in rats following single and multiple oral doses of LA-12 ((OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)). [J] . Sova P, Chladek J, Zak F, International Journal of Pharmaceutics . 2005,第1期

机译：单次和多次口服LA-12（（OC-6-43）-bis（acetato）（1-adamantylamine）amminedichloroplatinum（IV））后，铂在大鼠体内的药代动力学和组织分布。
3. Single-dose pharmacokinetics of a novel oral platinum cytostatic drug ((OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum (IV)) in pigs. [J] . Cermanova J, Chladek J, Soval P, Methods and findings in experimental and clinical pharmacology . 2004,第9期

机译：新型口服铂细胞抑制药物（（OC-6-43）-bis（acetato）（1-adamantylamine）amminedichloroplatinum（IV））的单剂量药代动力学。
4. Mechanism of action of an orally administered platinum complex ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221) in intrinsically cisplatin-resistant human ovarian carcinoma in vitro. [O] . M. J. McKeage, G. Abel, L. R. Kelland, 1994

机译：口服给予的铂络合物氨双丁酮环己胺二氯铂（IV）（JM221）在本质上对顺铂耐药的人卵巢癌的体外作用机理。
5. Pharmacokinetic and Pharmacodynamic Analysis of Bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) Administered Once a Day for Five Consecutive Days: A Phase I Study [O] . T. Kurata 2000

机译：双乙酰氨基 - 氨基 - 二氯 - 二氯 - 铂 - 铂（IV）（JM216）的药代动力学和药物动力学分析每天施用一次，连续五天给药：我研究了一阶段
6. Biodistribution and Pharamacokinetics of /Sup 195M/Pt-Labeled Cis-Dichlorotrans-Dihydroxo-Bis(Isopropylamine)Platinum(IV), CHIP, In Normal Female Fischer 344 Rat [R] . Hoeschele, J. D., Ferren, L. A., Roberts, J. A., 1983

机译：/ sup 195m / pt标记的顺式 - 二氯 - 二羟基 - 双（异丙胺）铂（IV），CHIp，在正常雌性Fischer 344大鼠中的生物分布和药代动力学

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