Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent

摘要

Purpose ML-970 (AS-I-145; NSC 716970) is an indolecarboxamide synthesized as a less toxic analog of CC-1065 and duocarmycin, a natural product that binds the A-T-rich DNA minor groove and alkylates DNA. The NCI60 screening showed that ML-970 had potent cytotoxic activity, with an average GI₅₀ of 34 nM. The aim of this study is to define the pharmacological properties of this novel anticancer agent.