Long term omeprazole therapy for reflux esophagitis: follow-up in serum gastrin levels, EC cell hyperplasia and neoplasia

摘要

AIM To evaluate the long-term safety of omeprazole in patients of gastroesophageal reflux disease resistant to treatment with H2 receptor antagonist. METHODS We prospectively followed 33 Patients on omeprazole therapy for severe Erosive esophagitis for 5-8 years, with periodic Gastrin levels, H. Pylori infection, gastric Bipsies for incidence of ECL cell hyperplasia, Carcinoinds, gastric atrophy and neoplasia.