Effects of AT1 receptor antagonist, losartan, on rat hepatic fibrosis induced by CCl_4

摘要

AIM To investigate effect of losartan, an AT1 receptor antagonist, on hepatic fibrosis induced by CCl_4; and to determine whether or not AT1 Receptors are expressed on hepatic stellate cells. METHODS AND RESULTS Fifty male Sprague- Dawley rats, weighing (180 ± 20) g, were Randomized into five groups (control group, model Group, and three losartan treated groups), in Which all rats were given the subcutaneous Injection of 40/100 CCl_4 (every 3 days for 6 weeks) Except for rats of control group. Rats of losartan- Treated groups were treated with losartan (20 mg/ Kg, 10 mg/kg, 5 mg/kg, daily davage).