Expression of lung resistance protein in patients with gastric carcinoma and its clinical significance

摘要

The efficacy of chemotherapy in the treatment of cancer patients is often hampered by the presence or appearance of multidrug resistance (MDR) of tumor cells. One of the most important mechanisms of MDR is overexpression of P-glycoprotein (Pgp) Which is encoded by mdr1 gene~[1]. Recently, Another MDR-related protein, lung resistance Protein (LRP), has been identified~[2]. Our primary Study indicated that LRP overexpressed in Gastrointestinal carcinoma. In this paper, the Expression of LRP in human gastric carcinoma and Its significance were studied.