Gastrin, somatostatin, G and D cells of gastric ulcer in rats

摘要

Conclusion: In gastric ulcer, the increased gastrin secreted by G cells, the declined somatostatin secreted by D cells, and the disordered G/D cell ratio can lead to gastrointestinal dysfunction. Aim: To investigate the relationship among gastrin, Somtostatin, G and D cells in gastric ulcer and in its Healing process in rats. Methods: Fourty-nine Wistar rats were divided into 7 Groups. the gastric ulcer model was induced by acetic acid Successfully. The gastrin and the somatostatin in rat Plasma, gastric fluid and antral tissue were measured by Radioimmunoassay(RA). G and D cells in antral mucosa Were analyzed with polyclonal antibody of gastrin and Somtostatin by immunohistochemical method and Quantimet 500 image analysis system.