Commentary: non-HIV hypotheses must be studied more carefully

摘要

Patients with haemophilia treated with commercial factor VIII and zidovudine are at risk of developing AIDS defining immunodeficiency diseases like pneumonia, candidiasis, and toxoplasmosis but not Kaposi's sarcoma or dementia. Their risk of these diseases is proportional to their lifetime dosages of factor VIII and cytotoxic DNA chain terminators like zidovudine. Haemophilia specific AIDS diseases have been explained in terms of two hypotheses. A non-infectious hypothesis holds that the long term administration of immunosuppressive foreign proteins contaminating commercial factor VIII and zidovudine causes AIDS. An infectious hypothesis holds that HIV causes AIDS.