Premature osteonecrosis and sirolimus treatment in renal transplantation

摘要

The incidence of osteonecrosis or avascular necrosis has fallen as a result of new advances in immunosuppression and lower corticosteroid regimens. Mycophenolate mofetil and sirolimus are associated with an increase in surgical complications. Sirolimus may also be associated with avascular necrosis in patients after renal allograft transplantation. This could be attributed to sirolimus's adverse lipid profile, its potent bone marrow suppressive effect, or perhaps an idiosyncratic effect.