Appraising organised screening programmes for testing for genetic susceptibility to cancer

摘要

Screening has expanded from early detection of disease or its precursors to include testing for susceptibility, such as genetic testing for cancer. The Wilson and Jungner framework for evaluating screening tests, produced for the World Health Organization in 1968, is commonly used for population screening. The relevance of this framework for testing for genetic susceptibility to cancer has not previously been assessed. A modified Wilson and Jungner framework can continue to provide a robust approach to evaluating testing for genetic susceptibility.