Risk of adenocarcinoma in Barrett's oesophagus: population based study

摘要

Endoscopic surveillance of Barrett's oesophagus is now routine. Cost effectiveness depends on the risk of oesophageal adenocarcinoma. The magnitude of this risk is unclear because most previously published studies were small and inconclusive. Except for one, these studies were not population based but investigated patients at one or more centres. Selection bias or the effect of common losses to follow up were not assessed. We investigated the risk of oesophageal malignancy in a large cohort of unselected patients with Barrett's oesophagus in Northern Ireland, where all incident cancers are routinely identified.