In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine

M.I.Colado; E.OShea; R.Granados

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In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine

机译：施用MDMA（'摇头丸'）和对氯苯丙胺后自由基参与大鼠脑5-HT变性的体内证据，但未显示芬氟拉明后自由基的参与

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摘要

We suggest that these different modes of action render untenable the recent suggestion that MDMA will not be neurotoxic in humans because fenfluramine appears safe at clinical doses.

机译：我们认为，这些不同的作用方式使最近的观点认为MDMA对人体无神经毒性，因为芬氟拉明在临床剂量下似乎是安全的，因此这一观点难以成立。

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来源
《British Journal of Pharmacology》 |1997年第5期|p.889-900|共12页
作者
M.I.Colado; E.OShea; R.Granados;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
3; 4-Methylenedioxymethamphetamine; ecstasy; neurodegeneration;

机译：3;4-亚甲基二氧甲基苯丙胺;狂喜;神经变性;
入库时间 2022-08-18 00:42:56

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1. In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism. [J] . Colado MI, OShea E, Esteban B, Neuropharmacology . 1999,第2期

机译：体内证据表明，氯吡咪唑可通过自由基清除机制对MDMA（'摇头丸'）诱导的大鼠大脑5-HT神经末梢变性具有神经保护作用。
2. Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3, 4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration [J] . M. I. Colado, E. OShea, R. Granados British Journal of Pharmacology . 1999,第4期

机译：研究多巴胺在3,4-亚甲基二氧基甲基苯丙胺（MDMA或'摇头丸'）给药后对黑暗Agouti大鼠大脑中5-HT神经末梢的变性作用
3. The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy"). [J] . Colado MI, Granados R, OShea E, Pharmacology and Toxicology: An International Journal . 1999,第6期

机译：大鼠3,4-亚甲二氧基苯丙胺（MDEA，“ eve”）对体温和脑中5-HT神经元长期变性的急性作用：与MDMA（“摇头丸”）的比较。
4. Implantable biocomposite based radical oxigen species scavengers as a therapeutic strategy to manage age related macular degeneration [C] . Marta O. Freitas, Ana S. Neto, B. Moreno, European conference on biomaterials . 2014

机译：基于可植入生物复合物的自由基氧清除剂，作为治疗与年龄相关的黄斑变性的治疗策略
5. In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model [D] . KITAMURA, Yuta 2019

机译：单一或联合使用局部神经保护和再生剂对大鼠视神经挤压模型中视网膜神经节细胞变性的体内作用
6. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA (‘ecstasy) and p-chloroamphetamine but not the degeneration following fenfluramine [O] . M I Colado, E OShea, R Granados, 1997

机译：给予MDMA（摇头丸）和对氯苯丙胺后自由基参与大鼠脑5-HT变性的体内证据但未显示芬氟拉明后自由基的参与
7. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA (‘ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine [O] . Colado, M I, O'Shea, E, Granados, R, 1997

机译：给予MDMA（摇头丸）和对氯苯丙胺后自由基参与大鼠脑5-HT变性的体内证据，但未显示芬氟拉明后自由基的参与
8. Mapping Toxicant-Induced Nervous System Damage with a Cupric Silver Stain: AQuantitative Analysis of Neural Degeneration Induced by 3,4-Methylenedioxymethamphetamine (MDMA) (Revised) [R] . Jensen, K. F. 1992

机译：用铜银染色法绘制毒物诱导的神经系统损伤：3,4-亚甲二氧基甲基苯丙胺（mDma）诱导的神经变性的定量分析（修订版）

In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine

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