A comparative study on the rat aorta and mesenteric arterial bed of the possible role of nitric oxides in the desensitization of the vasoconstrictor response to an α_1-adrenoceptor agonist

摘要

These results suggest that a desensitization to methoxamine develops rapidly in the mesenteric arterial bed, but not in the aorta, and that release of nitric oxide from the endothelium plays a major role in this desensitization.