Potent antihyperglycaemic property of a new imidazoline derivative S-22068(PMS 847) in a rat model of NIDDM

摘要

Recent data suggest that some imidazoline derivatives can lower plasma glucose in experimental animal models of diabetes. We studied the activity of an imidazoline S-22068, in rat model of non- insulin-dependent diabetes mellitus(NIDDM) produced with a low dose of streptozotocin(35 mg kg~-1, i.v.) in the adult. The respective increase over basal value in glucose(ΔG) and insulin(ΔI), and the rate of glucose Disappearance (K), were measured during a 30 min intravenous glucose tolerance test. After an Intraperitoneal injection of S-22068 (24 mg kg~-1), ΔG(mM min~-1) was decreased (91.67±5.83 vs 120.5±3.65; P<0.001), whereas K was increased (1.74 ±0.09 vs 1.18±0.05; P<0.001). although insulinaemia was increased at time-point 0 of the test, ΔI was unchanged.