Involvement of K~+ channel permeability changes in the L-NAME and indomethacin resistant part of adenosine-5'-O- (2-thiodiphosphate)-induced relaxation of pancreatic vascular bed

摘要

We have previously demonstrated that adenosine-5'-O-(2-thiodiphosphate) (ADPβS), a potent P2Y- purinoceptor agonist, relaxed pancreatic vasculature not only through prostacyclin (PGI_2) and nitric oxide(NO) release from the endothelium but also through other mechanisms(s). in this study, we investigated the effects of an inhibitor of the Na~+/K~+ pump, of ATP-sensitive K~+(K_ATP) channels and of small (SK_Ca) or large (BK_Ca) conductance Ca~2+ -activated K~+ channels. Experiments were performed at basal tone and during the inhibition of NO synthase and cyclo-oxygenase.