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首页> 外文期刊>British Journal of Pharmacology >Interaction of amiodarone and triiodothyronine on the expression of β-adrenoceptors in brown adipose tissue of rat
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Interaction of amiodarone and triiodothyronine on the expression of β-adrenoceptors in brown adipose tissue of rat

机译:胺碘酮与三碘甲状腺素相互作用对大鼠棕色脂肪组织中β-肾上腺素受体表达的影响

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摘要

1. This study was undertaken to evaluate in vivo the influence of amiodarone on the effects of triiodothyronine (T3) in brown adipose tissue (BAT) which are independent of thyroid hormone synthesis and of the conversion of thyroxine (T4) to T3. Thyroidectomized rats were given a replacement dose of T3 (0.5 mg kg~-1 p. o. Daily for 3 days) with or without amiodarone (50 mg kg~-1 p. o. Daily for 1 week).
机译:1.这项研究是为了评估体内胺碘酮对棕色脂肪组织(BAT)中三碘甲状腺素(T3)的影响,这种影响与甲状腺激素合成和甲状腺素(T4)向T3的转化无关。给予甲状腺切除的大鼠补充剂量的T3(0.5 mg kg〜-1 p.o.,每天3天),或不使用胺碘酮(50 mg kg〜-1 p.o.,每天1周)。

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